pentobarbital will reduce the level or effect of propafenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.
pentobarbital will enhance the stage or influence of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Caution when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone could raise and can result in most likely fatal respiratory depression.
pentobarbital will minimize the extent or impact of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Observe individuals previously on buprenorphine subdermal implant who involve freshly-initiated treatment with CYP3A4 inducer for indicators and symptoms of withdrawal.
pentobarbital will decrease the extent or impact of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Impact of coadministering a powerful CYP3A4 inducer with fedratinib hasn't been studied.
pentobarbital will lower the extent or result of nateglinide by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Monitor.
pentobarbital will decrease the extent or effect of lorlatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the extent or result of quetiapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will decrease the extent or influence of flurbiprofen by impacting hepatic enzyme CYP2C9/10 metabolism. read more Insignificant/Importance Unfamiliar.
pentobarbital will lower the level or effect of buspirone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the extent or influence of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with powerful CYP3A4 inducers can lead to reduced serum concentrations and loss of antimalarial efficacy
Monitor Intently (1)pentobarbital will reduce the level or influence of hydrocodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Warning when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone could improve and can result in likely deadly respiratory depressionSerious - Use Option (one)hydrocodone, pentobarbital.
pentobarbital will decrease the level or effect of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.
Reserve concomitant prescribing of those drugs in clients for whom other remedy selections are insufficient. Restrict dosages and durations into the minimum amount necessary. Check carefully for indications of respiratory melancholy and sedation.